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Wissenschaftliche Publikationen

Das internationale Expertenforum der Altersforschung

Die "Forschungsgruppe Gesundes Altern" publiziert die Ergebnisse ihrer wissenschaftlichen Arbeit und Skizzen ihrer Projekte zunächst in nationalen und internationalen Fachmagazinen.

 

Flachsbart F, Ufer M, Kleindorp R, Nikolaus S, Schreiber S, Nebel A. Genetic variation in the CYP2C monooxygenase enzyme subfamily shows no association with longevity in a german population (2011). J Gerontol A Biol Sci Med Sci. [Epub ahead of print]

 

Nebel A*, Kleindorp R*, Caliebe A*, Nothnagel M, Blanché H, Junge O, Wittig M, Ellinghaus D, Flachsbart F, Wichmann HE, Meitinger T, Nikolaus S, Franke A, Krawczak M, Lathrop M, Schreiber S (2011). A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals. Mech Ageing Dev. [Epub ahead of print]


Kleindorp R, Flachsbart F, Puca AA, Malovini A, Schreiber S, Nebel A (2011). Candidate gene study of FOXO1, FOXO4 and FOXO6 reveals no association with human longevity in Germans. Aging Cell 10:622-8.

 

Huebbe P*, Nebel A*, Siegert S, Moehring J, Boesch-Saadatmandi C, Most E, Pallauf J, Egert S, Müller MJ, Schreiber S, Nöthlings U*, Rimbach G* (2011). APOE e4 is associated with higher vitamin D levels in targeted replacement mice and humans. FASEB. [Epub ahead of print]


Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A (2010). Investigation of genetic susceptibility factors for human longevity - A targeted nonsynonymous SNP study. Mutat Res 694:13-9.


Caliebe A*, Kleindorp R*, Blanché H, Christiansen L, Puca AA, Rea IM, Slagboom E, Flachsbart F, Christensen K, Rimbach G, Schreiber S, Nebel A (2010). No or only population-specific effect of PON1 on human longevity: a comprehensive meta-analysis. Ageing Res Rev 9:238-44.


Flachsbart F, Caliebe A, Nothnagel M, Kleindorp R, von Eller-Eberstein H, Nikolaus S, Schreiber S, Nebel A (2010). A2M risk haplotype for Alzheimer disease is less frequent in long-lived individuals. Eur J Hum Genet 18:59-61.


Flachsbart F, Caliebe A, Kleindorp R, Blanché H, von Eller-Eberstein H, Schreiber S, Nebel A (2009). Association of FOXO3A variation with human longevity confirmed in German centenarians. Proc Natl Acad Sci U S A 106:2700-5.


Nebel A*, Flachsbart F*, Till A*, Caliebe A, Blanché H, Arlt A, Häsler R, Jacobs G, Kleindorp R, Franke A, Shen B, Nikolaus S, Krawczak M, Rosenstiel P, Schreiber S. A functional EXO1 promoter variant is associated with prolonged life expectancy in centenarians (2009). Mech Ageing Dev 130:691-9.


Lescai F, Blanché H, Nebel A, Beekman M, Sahbatou M, Flachsbart F, Slagboom E, Schreiber S, Sorbi S, Passarino G, Franceschi C (2009). Human longevity and 11p15.5: a study in 1321 centenarians. Eur J Hum Genet 17:1515-9.


Nebel A*, Flachsbart F*, Schäfer A, Nothnagel M, Nikolaus S, Mokhtari NE, Schreiber S (2007). Role of the toll-like receptor 4 polymorphism Asp299Gly in longevity and myocardial infarction in German men. Mech Ageing Dev 128:409-11.


Nebel A, Croucher PJ, El Mokhtari NE, Flachsbart F, Schreiber S (2007). Common coding polymorphisms in the ABCA1 gene and risk of early-onset coronary heart disease in northern Germany. Atherosclerosis 193:458-60.


Flachsbart F, Croucher PJ, Nikolaus S, Hampe J, Cordes C, Schreiber S, Nebel A (2006). Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity. Exp Gerontol 41:98-102.

 

Nebel A, Croucher PJ, Stiegeler R, Nikolaus S, Krawczak M, Schreiber S (2005). No association between microsomal triglyceride transfer protein (MTP) haplotype and longevity in humans. Proc Natl Acad Sci U S A 102:7906-9.


Flachsbart F, Nebel A, Nikolaus S, Schreiber S (2005). Genetic factors in longevity. Healthy living into old age - what role do genes play? Med Monatsschr Pharm 28:437-42. Review.


*gleichwertiger Beitrag der Autoren